Endocrine Abstracts

Knockout studies have demonstrated that FSHbeta knockout (FSHbKO) and FSH receptor knockout (FSHRKO) female mice are infertile due to block of follicle development at the pre-antral stage. The ovaries are reduced in size and uteri are atrophic. However, a proportion of FSHRKO and FSHbKO mice develop ovarian and uterine hypertrophy in middle age (Abel et al, 2001). In order to investigate further brain-pituitary-gonadal interrelationships the aim of the present study was to com...